ປະເພດຄຳຮ້ອງ
Patent - Foreign
ປະເພດຄຳຮ້ອງຍ່ອຍ
Patent - PCT National Phase
(10) ເລກທີ ແລະ ວັນທີການຈົດທະບຽນ
ສະຖານະ
Abandoned
(180) ມື້ໝົດອາຍຸ
(20) ເລກທີ ແລະ ມື້ ຍື່ນຄຳຮ້ອງ
LA P/729 12.02.2019
(40) ເລກທີ ແລະ ວັນທີເຜີຍແຜ່
(86) ເລກທີ ແລະ ວັນທີ ເອກະສານ PCT
(87) and Date ເລກທີ ແລະ ວັນທີ່ ເຜີຍແຜ່ PCT
(85) ວັນທີເອກະສານເຂົ້າ
(30) ລາຍລະອຽດບຸລິມະສິດ
FR 18157888.1
21.02.2018
(51) ການຈັດໝວດໝູ່ IPC
(71/73) ຜູ້ຍື່ນຄຳຮ້ອງ
(72) ຜູ້ປະດິດສ້າງ
(LA) ALMIRANTE, Nicoletta : Via Caracciolo, 26,20155 MILANO, Italy
(74) ຊຶ່ບໍລິສັດຕົວແທນ
(LA) Tilleke & Gibbins Lao Co.,Ltd : Road, Village, District, Vientiane Capital Lao PDR
(54) ຫົວຂໍ້
(LA) PROCESS FOR THE PREPARATION OF A NITRIC OXIDE DONATING PROSTAGLANDIN ANALOGUE
(57) ບົດສັງເຂບ
(LA)
The present invention relates to a process for preparing the hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]- 3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula (I). In accordance with the present invention, the compound (I) can be efficiently prepared with high purity by coupling bimatoprost in a boronate protected form with 6-(nitrooxy)hexanoyl chloride and removing the boronate protecting group. The 6-(nitrooxy)hexanoyl chloride intermediate is prepared by ring-opening reaction of 2-caprolactone and subsequent nitration of the 6-hydroxyhexanoic acid potassium salt with a mixture of HNO3 and H2SO4 in dichloromethane.
(58) ການຮຽກຮ້ອງ